Publications

Flagg, M.P., Wangeline, M.A., Holland, S.R., Duttke, S.H., Brenner, C., Neal, S., Hampton, R.Y., 2021, Inner-nuclear-membrane–associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity, Molecular Biology of the Cell, vol. 32, no. 7, pp. 521-537.

Wangeline, M.A., Hampton, R.Y., 2021, An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase, Journal of Biological Chemistry, vol. 296, pp. 100063.

Singh, A., Vashistha, N., Heck, J., Tang, X., Wipf, P., Brodsky, J.F., Hampton, R.Y., 2020, Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control, Molecular Biology of the Cell, vol. 31 no. 24, pp. 2669-2686.

Neal, S., Syau, D., Nejafard, A., Nadeau, S., Hampton, R.Y., 2020, HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation, Iscience, vol. 23, no. 9, pp. 101493.

Flagg, M.P., Kao, A., Hampton, R.Y., Year, Integrating after CEN Excision (ICE) Plasmids: Combining the ease of yeast recombination cloning with the stability of genomic integration, Yeast, vol. 36, no. 10, pp. 593-605.

Wangeline, M.A., Hampton, R.Y., 2019, Mallostery: Ligand-dependent Misfolding as a Strategy for Protein Regulation, The FASEB Journal, vol. 33, no. S1, pp. 351.3-351.3.

Neal, S., Duttke, S.H., Hampton, R.Y., 2019, Assays for protein retrotranslocation in ERAD, Methods in enzymology, vol. 619, pp. 1-26.

Wangeline, M.A., Hampton, R.Y., 2018, “Mallostery”—ligand-dependent protein misfolding enables physiological regulation by ERAD, Journal of Biological Chemistry, vol. 293, pp. 14937-14950.

Neal, S., Jaeger, P.A., Duttke, S.H., Brenner, C., Glass, C.K., Ideker, T., Hampton, R.Y., 2018, The Dfm1 Derlin is required for ERAD retrotranslocation of integral membrane proteins, Molecular Cell, vol. 69, no. 2, pp. 306-320.

Jaeger, P.A., Ornelas, L., McElfresh, C., Wong, L.R., Hampton, R.Y., Ideker, T., 2018, Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping, Molecular Cell, vol. 69, no. 2, pp. 321-333.

Wangeline, M.A., Vashistha, N., Hampton, R.Y., 2017, Proteostatic tactics in the strategy of sterol regulation, Annual Review of Cell and Developmental Biology, vol. 33, pp. 467-489.

Hampton, R.H., Dargemont, C., 2017, New developments for protein quality control, Science, vol. 357, no. 6350, pp. 450-451.

Neal, S., Mak, R., Bennet, E.J., Hampton, R.Y., 2017, A Cdc48 “Retrochaperone” Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates*, Journal of Biological Chemistry, vol. 292, no. 8, pp. 3112-3128.

Akula, M.K., Shi, M., Jiang, Z., Foster, C.E., Miao, D., Li, A.S., Zhang, X., Gavin, R.M., Forde, S.D., Germain, G., Carpenter, S., Rosadini, C.V., Gritsman, K., Chae, J.J., Hampton, R.H., Silverman, N., Gravallese, E.M., Kagan, J.C., Fitzgerald, K.A., Kastner, D.L., Goldenbock, D.T., Bergo, M.O., Wang, D., 2016, Control of the innate immune response by the mevalonate pathway, Nature Immunology, vol. 17, no. 8, pp. 922.

Vashistha, N., Neal, S., Singh, A., Carroll, S.M., Hampton, R.H., 2016, Direct and essential function for Hrd3 in ER-associated degradation, Proceedings of the National Academy of Sciences, vol. 113, no. 21, pp. 5934-5939.

Higgins, R., Gendron, J.M., Rising, L., Mak, R., Webb, K., Kaiser, S.E., Zuzow, N., Riviere, P., Yang, B., Fenech, E., Tang, X., Lindsay, S.A., Christianson, J.C., Hampton, R.Y., Wasserman, S.A., Bennett, E.J., 2015, The unfolded protein response triggers site-specific regulatory ubiquitylation of 40S ribosomal proteins, Molecular Cell, vol. 59, no. 1, pp 35-49.

Neal, S., Ornelas, L., Ruckstuhl, M., Singh, A., Tang, X., Vashistha, N., Wangeline, M.A., Hampton, R.H., 2014, Regulated quality control in physiological regulation of cellular processes: lessons from regulated ERAD of HMG‐CoA reductase (353.3), The FASEB Journal, vol. 28, no. S1, pp. 353.3.

Theesfeld, C.L., Hampton, R.Y., 2013, Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast, Journal of Biological Chemistry, vol. 288, no. 12, pp. 8519-8530.

Hampton, R.Y., Sommer, T., 2012, Finding the will and the way of ERAD substrate retrotranslocation, Current Opinion in Cell Biology, vol. 24, no. 4, pp. 460-466.

Li, S, Spooner, R.A., Hampton, R.Y., Lord, J.M., Roberts, L.M., 2012, Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p, PLoS One, vol. 7, no, 7, pp. e411119.

Theesfled, C.L., Pourmand, D., Davis, T., Garza, R.M., Hampton, R.Y., 2011, The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2*, Journal of Biological Chemistry, vol. 286, no. 30, pp. 26298-26307.

Hampton, R.Y., 2011, San1-mediated quality control: Substrate recognition “sans” chaperones, Molecular Cell, vol. 41, no. 1, pp. 2-3.

Carroll, S.M., Hampton, R.Y., 2010, Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase, vol. 285, no. 8, pp. 5146-5156.

Heck, J.W., Cheung, S.K., Hampton, R.Y, 2010, Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1, Proceedings of the National Academy of Sciences, vol. 107, no. 3, pp 1106-1111.

Garza, R.M., Tran, P.N., Hampton, R.Y., 2009, Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast, Journal of Biological Chemistry, vol. 284, no. 51, pp. 35368-35380.

Garza, R.M., Sato, B.K., Hampton, R.Y., 2009, In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, Journal of Biological Chemistry, vol. 284, no. 22, pp. 14710-14522.

Sato, B.K., Schulz, D., Do, P.H., Hampton, R.Y., 2009, Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase, Molecular Cell, vol. 34, no. 2, pp. 212-222.

Hampton, R.Y., Garza, R.M., 2009, Protein Quality Control as a Strategy for Cellular Regulation: Lessons from Ubiquitin-Mediated Regulation of the Sterol Pathway, Chemical Reviews, vol. 109, no. 4, pp. 1561-1574.

Hampton, R.Y., 2008, A Cholesterol Toggle Switch, Cell Metabolism, vol. 8, no. 6, pp. 451-453.

Federovitch, C.M., Jones, Y.Z., Tong, A.H., Boone, C., Prinz, W.A., Hampton, R.Y., 2008, Genetic and Structural Analysis of Hmg2p-induced Endoplasmic Reticulum Remodeling in Saccharomyces cerevisiae, Molecular Biology of the Cell, vol. 19, no. 10, pp. 4506-4520.

Bazirgan, O.A., Hampton, R.Y., 2008, Cue1p Is an Activator of Ubc7p E2 Activity in Vitro and in Vivo, Journal of Biological Chemistry, vol. 283, no. 19, pp. 12797-12810.

Hampton, R.Y., 2008, ERAD: mechanism and physiolgcial function, The FASEB Journal, vol. 22, pp. 98.2-98.2.

Chen, D., Gould, C., Garza, R., Gao, T., Hampton, R.Y., Newton, A.C., 2007, Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase, Journal of Biological Chemistry, vol. 282, no. 46, pp. 33776-33787.

Bazirgan, O.A., Garza, R.M., Hampton, R.Y., 2006, Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase, Journal of Biological Chemistry, vol. 281, no. 51, pp. 38989-39001.

Sato, B.K., Hampton, R.Y., 2006, Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis, Yeast, vol. 23, no. 14-15, pp. 1053-1064.

Flury, I., Garza, R., Shearer, A.G., Rosen, J., Cronin, S., Hampton, R.Y., 2005, INSIG: a broadly conserved transmembrane chaperone for sterol‐sensing domain proteins, The EMBO Journal, vol. 24, no. 22. pp. 3917-3926.

Federovitch, C.M., Ron, D., Hampton, R.Y., 2005, The dynamic ER: experimental approaches and current questions, Current Opinion in Cell Biology, vol. 17, no, 4, pp. 409-414.

Garza, R.M., Hampton, R.Y., 2005, Sterol sensor comes up for air, Nature, vol. 435, no. 7038, pp 37-38.

Bazirgan, O.A., Hampton, R.Y., 2005, Cdc48–Ufd2–Rad23: the road less ubiquitinated?, Nature Cell Biology, vol. 7, no. 3, pp. 207-209.

Hampton, R.Y., 2005, Fusion‐Based Strategies to Identify Genes Involved in Degradation of a Specific Substrate, Methods in Enzymology, vol. 399, pp. 310-323.

Ron, D., Hampton, R.Y., 2004, Membrane biogenesis and the unfolded protein response, Journal of Cell Biology, vol. 167, no. 1, pp. 23-25.

Shearer, A.G., Hampton, R.Y., 2004, Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase, Journal of Biological Chemistry, vol. 279, no. 1, pp. 188-196.

Hampton, R.Y., 2003, IRE1: a role in UPREgulation of ER degradation, Developmental Cell, vol. 4, no. 2, pp. 144-146.

Hampton, R.Y., 2002, Proteolysis and sterol regulation, Annual Review of Cell and Developmental Biology, vol. 18, no. 1, pp. 345-378.

Hampton, R.Y., 2002, ER-associated degradation in protein quality control and cellular regulation, Current Opinion in Cell Biology, vol. 14, no. 4, pp. 476-482.

Cronin, S.R., Rao, R., Hampton, R.Y., 2002, Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca²⁺ homeostasis, Journal of Cell Biology, vol. 157, no. 6, pp. 1017-1028.

Bays, N.W., Hampton, R.Y., 2002, Cdc48–Ufd1–Npl4: stuck in the middle with Ub, Current Biology, vol. 12, no. 10, pp. R366-R371.

Bays, N.W., Wilhovsky, S.K., Goradia, A., Hodgkiss-Harlow, K., Hampton, R.Y., 2001, HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins, Molecular Biology of the Cell, vol. 12, no. 12, pp. 4114-4128.

Gardner, R.G., Shearer, A., Hampton, R.Y., 2001, In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation, Molecular and Cellular Biology, vol. 21, no. 13., pp. 4276-4291.

Gardner, R.G., Shan, H., Matsuda, S.P.T., Hampton, R.Y., 2001, An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast, Journal of Biological Chemistry, vol. 276, no. 12, pp. 8681-8694.

Bays, N.W., Gardner, R.G., Seelig, L.P., Joazeiro, C.A., Hampton, R.Y., 2001, Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation, Nature Cell Biology, vol. 3, no. 1, pp. 24-29.

Gardner, R.G., Swarbrick, G.M., Bays, N.W., Cronin, S.R., Wilhovsky, S., Seelig, L., Kim, C., Hampton, R.Y., 2000, Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling: Transmembrane Control of Hrd1p by Hrd3p, Journal of Cell Biology, vol. 151, no. 1, pp. 69-82.

Hampton, R.Y., 2000, ER stress response: getting the UPR hand on misfolded proteins, Current Biology, vol. 10, no. 14, pp. R518-R521.

Wilhovsky, S. Gardner, R.G., Hampton, R.Y., 2000, HRD Gene Dependence of Endoplasmic Reticulum-associated Degradation, Molecular Biology of the Cell, vol. 11, no. 5, pp. 1697-1708.

Hampton, R.Y., 2000, Cholesterol homeostasis: ESCAPe from the ER, Current Biology, vol. 10, no. 8, pp. R298-R301.

Cronin, S.R., Khoury, A., Ferry, D.K., Hampton, R.Y., 2000, Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p, Journal of Cell Biology, vol. 148, no. 5, pp. 915-924.

Gardner, R.G., Hampton, R.Y., 1999, A ‘distributed degron’allows regulated entry into the ER degradation pathway, The EMBO Journal, vol. 18, no. 21, pp. 5994-6004.

Gardner, R.G., Hampton, R.Y., 1999, A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes, Journal of Biological Chemistry, vol. 274, no. 44, pp. 31671-31678.

Cronin, S.R., Hampton, R.Y., 1999, Measuring protein degradation with green fluorescent protein, Methods in Enzymology, vol. 302, pp. 58-73.

Gardner, R.G., Cronin, S.R., Leader, B., Rine, J., Hampton, R.Y., 1998, Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein, Molecular Biology of the Cell, vol. 9, no. 9, pp. 2611-2626.

Finley, D., Tanaka, K., Mann, C., Feldmann, H., Hochstrasser, M., Vierstra, R., Johnston, S., Hampton, R.Y., Haber, J., McCusker, J., Silver, P., Frontali, L., Thorsness, P., Varshavksky, A., Byers, B., Madura, K., Reed, S.I., Wolf, D., Jentsch, S., Sommer, T., Baumeister, W., Goldberg, A., Fried, V., Rubin, D.M., Glickman, M.H., Toh-e, A., 1998, Unified nomenclature for subunits of the Saccharomyces cerevisie proteasome regulatory particle, Trends in Biochemical Sciences, vol. 23, no. 7, pp. 244-245.

Hampton, R.Y., 1998, Genetic analysis of hydroxymethylglutaryl‐coenzyme A reductase regulated degradation, Current Opinion in Lipidology, vol. 9, no. 2, pp. 93-97.

Hampton, R.Y., Bhakta, H., 1997, Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase, PNAS, vol. 94, no. 24, pp. 12944-12948.

Donald, K.A., Hampton, R.Y., Fritz, I.B., 1997, Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae, Applied and Environmental Microbiology, vol. 63, no. 9, pp. 3341-3344.

Hampton, R.Y., Gardner, R.G., Rine, J., 1996, Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein, Molecular Biology of the Cell, vol. 7, no. 12, pp. 2029-2044.

Hampton, R.Y., Dimster-Denk, D., Rine, J., 1996, The biology of HMG-CoA reductase: the pros of contra-regulation, Trends in Biochemical Sciences, vol. 12, no. 4, pp. 140-145.

Hampton, R.Y., Koning, A., Wright, R., Rine, J., 1996, In vivo examination of membrane protein localization and degradation with green fluorescent protein, PNAS, vol. 93, no. 2, pp. 828-833.

Hampton, R.Y., Rine, J., 1994, Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast, The Journal of Cell Biology, vol. 125, no. 2, pp. 299-312.